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1.
药物相互作用改变了剂量效应关系,可能会降低疗效或增加毒性,是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义,体内和体外研究的主要内容;梳理分析了2020年国家药品监督管理局(National Medical Products Administration, NMPA)和美国食品药品监督管理局(Food and Drug Administration, FDA)批准上市的新药药物相互作用研究情况,旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。 相似文献
2.
In this study, sea bream, sea bass, anchovy and trout were captured and recorded using a digital camera during refrigerated storage for 7 days. In addition, their total viable counts (TVC) were determined on a daily basis. Based on the TVC, each fish was classified as ‘fresh’ when it was <5 log cfu per g, and as ‘not fresh’ when it was >7 log cfu per g. They were uploaded on a web-based machine learning software called Teachable Machine (TM), which was trained about the pupils and heads of the fish. In addition, images of each species from different angles were uploaded to the software in order to ensure the recognition of fish species by TM. The data of the study indicated that the TM was able to distinguish fish species with high accuracy rates and achieved over 86% success in estimating the freshness of the fish species tested. 相似文献
3.
Marcus Reppich Zdeněk Jegla Jakob Grondinger Yaovi Ouézou Azouma Vojtěch Turek 《化学,工程师,技术》2021,93(10):1581-1589
This study investigates the behavior of fruit and vegetable samples during drying. The experimental data are fitted to several different thin-layer drying models. Regression analysis is used to determine model parameters, while statistical indicators serve to evaluate the goodness of fit. The power function model gives the best fit for all examined samples. Based on this model, different drying and heat storage technologies can be combined to ensure that the required residual moisture content of an agricultural product is reached. It is demonstrated on the case of a specific Togolese processing plant that under favorable conditions, fossil fuel consumption can be decreased by 33 %. 相似文献
4.
目的 了解公众对网络食品药品谣言信息及虚假宣传甄别能力和行为态度,探索防范谣言传播、维护社会稳定的有效措施和途径。方法 采用随机抽样研究方法,对贵州省某少数民族自治州公众开展食品药品网络谣言及虚假宣传辨识能力、行为态度问卷调查。结果 当地公众食品药品网络谣言及虚假宣传辨识能力总体较低,经济发展落后地区的青少年人群对网络谣言及虚假宣传的辨识能力较弱。大部分公众处理网络食品药品安全信息较为理性,更愿意通过国家监管部门权威网站了解信息,基本具备了确认信息真实性的主观意识,但辟除谣言的行动能力不高。结论 地方党委政府及有关部门应加强食品药品网络谣言和虚假宣传治理,加大当地谣言及虚假宣传的监测和系统性分析研究,有针对性、预判性地进行治理和科普宣传。 相似文献
5.
Whereas large-scale consumption of energy-dense foods contributes to climate change, we investigated whether exposure to climate change-induced food scarcity affects preferences toward these foods. Humans’ current psychological mechanisms have developed in their ancestral evolutionary past to respond to immediate threats and opportunities. Consequently, these mechanisms may not distinguish between cues to actual food scarcity and cues to food scarcity distant in time and space. Drawing on the insurance hypothesis, which postulates that humans should respond to environmental cues to food scarcity through increased energy consumption, we predicted that exposing participants to climate change-induced food scarcity content increases their preferences toward energy-dense foods, with this effect being particularly pronounced in women. Three experiments—including one preregistered laboratory study—confirm this notion. Our findings jointly demonstrate that receiving information about food shortages distant in time and space can influence current food preferences. 相似文献
6.
Iratxe Perez-Arnedo María J. Cantalejo Alba Martínez-Laorden Elena Gonzalez-Fandos 《International Journal of Food Science & Technology》2021,56(4):1855-1864
Microbiological contamination of chicken meat depends on the conditions under which the animals are reared, slaughtered and processed. The aim of this study was to determine the influence of farm origin and processing stages at slaughterhouse on the microbial safety and quality of chicken. Samples of chicken carcasses from three different farms were taken from a slaughterhouse. Mesophiles, Escherichia coli, coagulase positive Staphylococcci counts, presence of Listeria monocytogenes,Campylobacter and Salmonella were determined at five sampling points: after defeathering, after evisceration, after washing, after chilling and after cutting. Chilling reduced log numbers of mesophiles, coagulase positive Staphylococci and E. coli by 0.85, 1.52 and 2.2 log units, respectively. Salmonella was not detected after chilling. High prevalence of Campylobacter spp was observed at all the stages ranging between 84% and 100%. L. monocytogenes was not detected in chicken carcasses after defeathering. However, it was detected after evisceration and after washing and chilling. The most critical stage for L. monocytogenes contamination was the portioning operation, the prevalence in breast and legs being 88% and 84%, respectively. 相似文献
7.
BackgroundGluten- and lactose-free products are registering a sudden rise in the market, particularly among tolerant people, and this leads to consumer confusion and nutritional inadequacies. The number of studies around this trend has steadily increased in the last 10 years, as scholars from different disciplines have tried to rationalize consumers’ behaviours in these foods’ choice. However, the scientific debate appears fragmented and lacks an integrated view.ObjectivesWe conducted a systematic integrative review of consumers’ determinants of gluten-free and lactose-free consumption to frame the state of the art and research gaps.Methods45 English language articles reporting quantitative empirical studies ranging from 1971 and 2019 were analysed. First we categorized the consumption determinants in six factors applying the model proposed by Koster and Mojet, then we proposed a new integrated conceptualization inspired by Bronfenbrenner’s Transtheoretical Model. Moreover, differences and similarities between tolerant and intolerant consumers will be highlighted.ResultsResearch on intolerant consumers focused more on individuals’ determinants, in terms of awareness, trust, morality, and capability to read nutritional facts (as purchase facilitators); while studies targeting tolerant consumers focused more on objective product characteristics (with price and availability in supermarkets as barriers for consumption). In this target the subjective perspective has been studied only referring to the risk for developing psychological issues in the restrictive diet.ConclusionAs information is lacking in the scientific debate, we suggest for future research the integration of consumers’ subjective implicit levers to decipher free-from purchase behaviours. 相似文献
8.
Grace Lara Chieko Takahashi Miku Nagaya Kunihiko Uemura 《International Journal of Food Science & Technology》2022,57(6):3251-3262
The present study aimed to investigate the influence of radio frequency (RF) heating at 70 and 80 °C, in comparison with the traditional conventional heating. The RF heating technology was applied for maintaining the colour and textural quality as well as inactivating the enzymatic activity of polyphenol oxidase (PPO) and reducing the Escherichia coli growth in packaged fresh-cut peach samples. To evaluate this, 120 g of freshly cut peach fruit was placed in heat-resistant plastic bags, and 50 mL of sugar solution (12°Brix) was added to each bag and vacuum-packed for conventional heating and radio frequency (RF) heating. Our results demonstrated that the RF heating process could reduce the heating time by up to 83% at 70 and 80 °C as compared to conventional heating. Moreover, RF heating at 70 and 80 °C reduced the PPO enzymatic activity, which caused enzymatic browning, up to 85.46% and 93.5%, respectively, as compared to 40.86% reduction only for conventional heating. Furthermore, RF heating completely inhibited E. coli growth. Collectively, we demonstrated that RF heating is an emerging and promising technology for improving the quality of fresh-cut fruits such as peach during various storage conditions. The present study provides relatively novel information on the effectiveness of RF heating in maintaining the quality of fresh-cut peaches. In the future, we would like to investigate the effectiveness of RF heating on other agricultural products. 相似文献
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10.
Nutritional warnings are rapidly gaining relevance, particularly in the region of the Americas, as a front-of-package nutrition labelling scheme that facilitate the identification of products with high content of nutrients associated with non-communicable diseases (NCDs). Several graphic designs are being developed as countries discuss the implementation of nutritional warnings, which makes it necessary to develop research to evaluate their efficacy. In this context, the aim of the present work was to compare the efficacy of a series of nutritional warnings that are being considered by Brazilian national authorities for the country with two of the most studied schemes: the guidelines daily amounts (GDA) and the traffic light system. Two studies were conducted. In the first one, visual search was conducted with 62 participants to evaluate the time needed by them to identify the schemes on food labels and to identify whether a product had high nutrient content. In the second study, an online survey with 1932 participants was used to evaluate their ability to use FOP nutrition labelling schemes to correctly identify the most healthful product in a set, as well as high nutrient content in a product. In addition, the influence of FOP nutrition labelling schemes on perceived healthfulness was evaluated. Finally, consumers’ perception of the schemes was gathered using an open-ended question. Results confirmed the advantages of nutritional warnings compared to the GDA and the traffic-light system to facilitate the identification of products with high content of nutrients associated with NCDs. In addition, the use of familiar signs frequently used to convey a ‘warning message’ outperformed other unfamiliar signs in terms of their ability to facilitate the interpretation of nutrition information. Regarding colour, black signs tended to required significantly less time to be detected when included on colour food labels compared to red signs. 相似文献